12/15-lipoxygenase-dependent myeloid production of interleukin-12 is essential for resistance to chronic toxoplasmosis Running title: 12/15-LOX regulates IL-12 in Chronic Toxoplasmosis
نویسندگان
چکیده
Abbreviations: 12/15-LOX, 12/15-lipoxygenase; 5-LOX, 5-lipoxygenase; 5/12/15(S)HETE , 12/15(S)-hydroxyeicosatetraenoic acid; 13(S)-HODE, 13(S)hydroxyoctadecadienoic acid; LxA4, lipoxin A4; STAg, soluble toxoplasma antigen; ICSBP, Interferon Consensus Sequence Binding Protein; IRF-8, Interferon Regulatory Factor-8, BMNCs, Brain Mononuclear Cells Copyright © 2009, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. Infect. Immun. doi:10.1128/IAI.00560-09 IAI Accepts, published online ahead of print on 12 October 2009
منابع مشابه
12/15-lipoxygenase-dependent myeloid production of interleukin-12 is essential for resistance to chronic toxoplasmosis.
Interleukin-12 (IL-12) is critical for resistance to Toxoplasma gondii during both the acute and chronic stages of infection. However, the cellular and molecular pathways that regulate IL-12 production during chronic toxoplasmosis are incompletely defined. We recently discovered that 12/15-lipoxygenase (12/15-LOX), which oxidizes unsaturated lipids in macrophages, is a novel and selective regul...
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